- Open Access
Brevican “nets” voltage-gated calcium channels at the hair cell ribbon synapse
© Conant et al. 2018
- Published: 26 September 2018
The original article was published in BMC Biology 2018 16:99
During hearing in mammals, “sensorineural” inner hair cells convert sound wave-generated mechanical input into electrical activity, resulting in glutamate release onto type I spiral ganglion neurons (SGNs) at specialized synapses known as “ribbon synapses”. New findings published here in BMC Biology by Sonntag and colleagues indicate a role for the proteoglycan Brevican in forming perineurounal net (PNN) baskets at these synapses and controlling the spatial distribution of presynaptic voltage-gated calcium channels that regulate glutamate release. These findings may provide insight into the mechanism by which individual ribbon synapses within a single hair cell can function in an independent manner to facilitate hearing within a broad dynamic range.
We apologize to investigators whose excellent work could not be directly cited due to publisher limits.
TC is supported by a grant from the Mathers Foundation, and NIH grants R01DC016595 and R00DC13107. KC is supported by NIH grant R01NS108810.
TMC and KC both wrote sections and edited/discussed the overall contribution. Both authors read and approved the final manuscript.
The authors declare that they have no competing interests.
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- Liberman LD, Liberman MC. Postnatal maturation of auditory-nerve heterogeneity, as seen in spatial gradients of synapse morphology in the inner hair cell area. Hear Res. 2016;339:12–22.View ArticleGoogle Scholar
- Shrestha BR, Chia C, Wu L, Kujawa SG, Liberman MC, Goodrich LV. Sensory neuron diversity in the inner ear is shaped by activity. Cell. 2018;174:1229–46 e17.View ArticleGoogle Scholar
- Sonntag M, Blosa M, Schmidt S, Reimann K, Blum K, Eckrich T, Seeger G, et al. BMC Biol. 2018. https://doi.org/10.1186/s12915-018-0566-8.
- Cabungcal JH, Steullet P, Morishita H, Kraftsik R, Cuenod M, Hensch TK, et al. Perineuronal nets protect fast-spiking interneurons against oxidative stress. Proc Natl Acad Sci U S A. 2013;110:9130–5.View ArticleGoogle Scholar
- Frischknecht R, Heine M, Perrais D, Seidenbecher CI, Choquet D, Gundelfinger ED. Brain extracellular matrix affects AMPA receptor lateral mobility and short-term synaptic plasticity. Nat Neurosci. 2009;12:897–904.View ArticleGoogle Scholar
- Favuzzi E, Marques-Smith A, Deogracias R, Winterflood CM, Sanchez-Aguilera A, Mantoan L, et al. Activity-dependent gating of parvalbumin interneuron function by the perineuronal net protein brevican. Neuron. 2017;95:639–55 e10.View ArticleGoogle Scholar
- Picher MM, Gehrt A, Meese S, Ivanovic A, Predoehl F, Jung S, et al. Ca(2+)-binding protein 2 inhibits Ca(2+)-channel inactivation in mouse inner hair cells. Proc Natl Acad Sci U S A. 2017;114:E1717–E26.View ArticleGoogle Scholar
- Brandt A, Striessnig J, Moser T. CaV1.3 channels are essential for development and presynaptic activity of cochlear inner hair cells. J Neurosci. 2003;23:10832–40.View ArticleGoogle Scholar
- Guinan JJ Jr. Olivocochlear efferents: their action, effects, measurement and uses, and the impact of the new conception of cochlear mechanical responses. Hear Res. 2018;362:38–47.View ArticleGoogle Scholar
- Wu JS, Young ED, Glowatzki E. Maturation of spontaneous firing properties after hearing onset in rat auditory nerve fibers: spontaneous rates, refractoriness, and interfiber correlations. J Neurosci. 2016;36:10584–97.View ArticleGoogle Scholar