- Open Access
To Mia or not to Mia: stepwise evolution of the mitochondrial intermembrane space disulfide relay
© Carrie et al. 2017
- Published: 14 December 2017
The disulfide relay system found in the intermembrane space (IMS) of mitochondria is an essential pathway for the import and oxidative folding of IMS proteins. Erv1, an essential member of this pathway, has been previously found to be ubiquitously present in mitochondria-containing eukaryotes. However, the other essential protein, Mia40, was found to be absent or not required in some organisms, raising questions about how the disulfide relay functions in these organisms. A recent study published in BMC Biology demonstrates for the first time that some Erv1 proteins can function in oxidative folding independently of a Mia40 protein, providing for the first time strong evidence that the IMS disulfide relay evolved in a stepwise manner.
See research article: 10.1186/s12915-017-0445-8
Financial support provided by the German Research Council (DFG, CA1775/1-1 to CC) is acknowledged.
CC and JS wrote the manuscript together and agreed to the content. Both authors read and approved the final version.
The authors declare that they have no competing interests.
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