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  • Erratum
  • Open Access

Erratum to: The majority of total nuclear-encoded non-ribosomal RNA in a human cell is 'dark matter' un-annotated RNA

  • 1Email author,
  • 2, 8,
  • 1,
  • 1,
  • 3,
  • 4,
  • 5,
  • 1,
  • 6,
  • 1Email author and
  • 7Email author
BMC Biology20119:86

https://doi.org/10.1186/1741-7007-9-86

  • Received: 16 December 2011
  • Accepted: 20 December 2011
  • Published:

The original article was published in BMC Biology 2010 8:149

The publisher notes typographical errors which were introduced to the first paragraph of page 10 (beginning "Previously, human large intergenic non-coding (linc) RNAs were identified in normal human embryonic and stem cell lines...") during the production process. The publisher apologises for the errors caused. The online article HTML was corrected on 19 October 2011, and the article PDF on 31 October 2011; readers with previous versions of the article are advised to update to the corrected version [1].

Corrected paragraph:

"Previously, human large intergenic non-coding (linc) RNAs were identified in normal human embryonic and stem cell lines [twenty seven] and we sought to determine whether the vlinc regions were overlapping those. In fact, the majority of the vlinc transcribed regions we have identified did not overlap the known human lincRNA regions and, thus, represent novel RNAs that are also large, intergenic and non-coding, as exemplified in the four examples shown (Figure four c and four d, Figure five a and five b). These latter regions have known lincRNA regions located nearby, without overlap, while the former do not have lincRNA regions in their vicinity. Furthermore, the intergenic regions identified here achieve much greater lengths than known lincRNAs, with a median size of ~84 kb versus 21 kb for the lincRNAs (significant at P = 1.72 × 10-53, t-test). Overall, 37% (215/580) of the vlinc regions overlapped the K4-K36 domains harbouring lincRNAs as reported by Khalil et al. [twenty seven]. However, even when overlapping, the lincRNA regions corresponded to only a fraction of our intergenic regions: the overlap of base pairs in the intergenic regions found here with the lincRNA regions was only approximately 19% (13.51/68.51 Mbp). However, the overlap between the two categories of the intergenic transcribed regions is highly significant (P-value < 10-16, chi-square test)."

Notes

Authors’ Affiliations

(1)
Helicos BioSciences Corporation, One Kendall Square, Building 700, Cambridge, MA 02139, USA
(2)
Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, SFH Life Sciences Building, 185 Meeting St, Providence, RI 02912, USA
(3)
Cancer Center, Departments of Cell Biology & Biochemistry, Pediatrics, and Internal Medicine, School of Medicine, Texas Tech University Health Sciences Center, 3601 4th Street STOP 9445, Lubbock, TX 79430-6450, USA
(4)
British Columbia Cancer Research Centre, 675 West 10th Avenue, Room 4112, Vancouver, BC, Canada, V5Z 1L3
(5)
Department of Pediatrics, The George Washington University School of Medicine and Health Sciences, Division of Oncology, Children's National Medical Center, 11 Michigan Ave, NW, Washington, DC 20422, USA
(6)
Department of Oncology/Pediatric Oncology, Kimmel Comprehensive Cancer Center at John Hopkins, The Buntings Blaustein Cancer Research Building, 1650 Orleans Street, Suite 207, Baltimore, MD 21287, USA
(7)
Department of Pathology, University of Southern California, 1975 Zonal Avenue, Los Angeles, CA 90089-9034, USA
(8)
Grupo de Inmunovirologia, SIU, Universidad de Antioquia, Calle 67 Número 53 - 108, Medellin, Antioquia, Colombia

References

  1. Kapranov P, St Laurent G, Raz T, Ozsolak F, Reynolds CP, Sorenson PHB, Reaman G, Milos P, Arceci RJ, Thompson JF, Triche TJ: The majority of total nuclear-encoded non-ribosomal RNA in a human cell is 'dark matter' unannotated RNA. BMC Biol. 2010, 8: 149-10.1186/1741-7007-8-149.PubMed CentralView ArticlePubMedGoogle Scholar

Copyright

© Kapranov et al; licensee BioMed Central Ltd. 2011

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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